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Related Experiment Video

Updated: Jun 8, 2026

Concurrent Collection of Fetal Murine Brain and Serum to Assess Effects of Maternal Diet on Nutrition and Neurodevelopment in Neurofibromatosis Type 1

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Aggressive infantile fibromatosis.

D P Yesudian¹, S G Krishnan, M Jayaraman

¹Department of Dermatology, Madras Medical College and Government General Hosptial, Madras, India.

Indian Journal of Dermatology, Venereology and Leprology

|October 16, 2010

Summary

An aggressive infantile fibromatosis, a rare childhood fibrous tumor, was diagnosed in an infant with rapidly growing skin lesions. Histopathology confirmed fusiform fibroblast proliferation, suggesting this juvenile fibromatosis type.

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Area of Science:

Pediatric Dermatology
Surgical Pathology
Oncology

Background:

Juvenile fibromatoses are a group of fibrous tissue tumors that manifest at birth or in early childhood.
Infantile fibromatosis represents a subset of these conditions, characterized by localized fibrous proliferation.

Purpose of the Study:

To present a case of aggressive infantile fibromatosis in an infant.
To highlight the clinical and histopathological features aiding in diagnosis.

Main Methods:

Clinical examination of an 8-month-old infant with skin lesions on the lower limb.
Histopathological analysis of biopsied tissue, focusing on cellular morphology and arrangement.

Main Results:

The infant presented with two ulcerated, indurated plaques on the right lower limb.
Biopsy revealed a proliferation of fusiform fibroblasts, with some arranged in whorls.
Lesion growth initially rapid, but stabilized over the preceding two months.

Conclusions:

The clinical presentation and histopathological findings strongly supported a diagnosis of aggressive infantile fibromatosis.
This case underscores the importance of considering juvenile fibromatoses in the differential diagnosis of pediatric skin tumors.