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In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
Published on: October 27, 2020
The possible risk for strokes complicating cardiac surgery in patients with intraoperative hypothermia
Isabelle Korn-Lubetzki1, Israel Steiner, Avraham Oren
1Department of Neurology, Shaare Zedek Medical Center, Jerusalem, Israel. ikl@cc.huji.ac.il
Insights
Intraoperative hypothermia below 30°C during cardiac surgery, especially with valve repair and coronary artery bypass grafting (CABG), may increase stroke risk. Lower temperatures around 28°C were linked to higher stroke incidence.
Area of Science:
- Cardiology
- Neurology
- Surgical Outcomes
Background:
- The neuroprotective role of hypothermia in cardiac surgery remains debated.
- Understanding factors influencing stroke after cardiac procedures is critical.
Purpose of the Study:
- To investigate the association between intraoperative temperature and postoperative stroke risk in cardiac surgery patients.
- To identify specific surgical procedures and patient factors contributing to stroke.
Main Methods:
- Retrospective analysis of cardiac surgery patients over 14 years.
- Comparison of patients with and without postoperative stroke.
- Multivariate analysis of pre- and intraoperative risk factors.
Main Results:
- Stroke occurred more frequently in patients undergoing valve repair/replacement combined with coronary artery bypass grafting (CABG) versus CABG alone.
- All strokes were ischemic, with a large-vessel etiology.
- Intraoperative minimal temperatures below 34°C were observed in all stroke patients, with lower temperatures (<30°C) significantly associated with stroke.
- Lower intraoperative temperature was an independent risk factor for stroke (OR 1.080/1°C).
Conclusions:
- Intraoperative hypothermia, particularly temperatures around 28°C, may be associated with an increased risk of postsurgical stroke.
- Specific procedures like combined valve repair/replacement and CABG may carry a higher stroke risk.
- Maintaining optimal intraoperative temperatures is crucial for mitigating stroke risk in cardiac surgery.
Background:
The effect of hypothermia as a possible neuroprotective tool on the outcome of cardiac surgery is still controversial.
Methods:
We retrospectively assessed all patients who underwent cardiac surgery within a 14-year period and compared patients with and without postoperative stroke.
Results:
Stroke occurred more frequently in patients who underwent valve repair/replacement combined with coronary artery bypass grafting (CABG) than in patients who had CABG alone (p = 0.0002). All strokes (1.4%) were ischemic and mostly of large-vessel etiology. All patients with stroke had intraoperative minimal temperature <34°C. More patients in this group than in the group without stroke had an intraoperative minimal temperature <30°C (p = 0.01). Stepwise multivariate analysis of all pre- and intraoperative parameters identified significant risk factors for stroke: hypertension, diabetes mellitus and previous stroke as preoperative risk factors, but only lower minimal temperature as a significant intraoperative risk factor (p = 0.03; odds ratio 1.080/1°C, 95% confidence interval 1.004-1.152). The mean intraoperative temperature was 28 ± 4°C in patients who developed stroke and 30 ± 3°C in patients without stroke.
Conclusions:
Intraoperative hypothermia around 28°C might be harmful and associated with increased risk for postsurgical stroke.
Related Concept Videos
Decreased Body Temperature
Ischemic Stroke l: Introduction
Ischemic Stroke ll: Pathophysiology
Cardiac Catheterization I: Pre-Procedure Overview
Hemorrhagic Stroke l: Introduction

