[Feasibility of adjuvant docetaxel plus cyclophosphamide therapy for breast cancer]
Koma Naito1, Shoji Oura, Tatsuya Yoshimasu
1Department of Thoracic and Cardiovascular Surgery, Wakayama Medical University.
Purpose:
To evaluate the feasibility of adjuvant docetaxel plus cyclophosphamide(TC)therapy for breast cancer.
Patients And Methods:
A total of 16 patients with intermediate risk-breast cancer were enrolled. TC therapy consisted of four courses of docetaxel 75 mg/m² plus cyclophosphamide 600 mg/m² intravenous administration over three weeks. Every infusion was premedicated with intravenous administration of granisetron 3 mg plus dexamethasone 16 mg, followed by dexamethasone 8 mg p. o. on days 2 and 3.
Results:
Due to the allergic reaction, one patient discontinued TC therapy. Fifteen (94%) of the 16 patients completed the scheduled TC therapy. Feasibility was 93.7%. Grade 3/4 toxicity was limited to leucopenia, neutropenia, and febrile neutropenia. No non-hematological serious adverse events were observed.
Conclusion:
Adjuvant TC therapy is a feasible option for breast cancer.
