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[Nephropathy in rheumatoid arthritis].

A Onetti Muda1, F Stella, T Faraggiana

  • 1Dipartimento di biopatologia umana, Università degli Studi di Roma, La Sapienza.

Pathologica
|November 1, 1990
PubMed
Summary

Rheumatoid arthritis can directly affect the kidneys, causing glomerulonephritis, vasculitis, and interstitial nephritis. This review explores primary kidney lesions in rheumatoid arthritis patients beyond drug side effects.

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Area of Science:

  • Nephrology
  • Rheumatology
  • Immunology

Context:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease primarily affecting joints.
  • Renal involvement in RA is traditionally considered secondary to amyloidosis or drug toxicity.
  • Emerging evidence suggests direct kidney pathology in RA.

Purpose:

  • To review current data on primary renal lesions in Rheumatoid arthritis.
  • To highlight the spectrum of kidney involvement directly associated with RA.

Summary:

  • The paper examines glomerulonephritis and amyloidosis in RA patients.
  • It discusses vasculitis, arterial changes, and chronic interstitial nephritis.
  • Lesions related to gold and penicillamine therapy are also reviewed.

Impact:

  • This review underscores the importance of monitoring kidney health in RA patients.
  • It provides a comprehensive overview of direct renal manifestations of RA.
  • Understanding these primary lesions can improve patient management and outcomes.

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