Related Experiment Video
Updated: Jun 8, 2026

Generation of Patient-Derived Podocytes from Skin Biopsies
Published on: May 26, 2023
What's a CLIC doing in the podocyte?
1Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina, UNC Kidney Center, Chapel Hill, North Carolina 27514, USA. jedwards@med.unc.edu
Abstract:
Chloride intracellular channel (CLIC) proteins are proposed to have numerous functions, including chloride channel activity, regulation of gene expression, and serving as a component of the cytoskeleton. Pierchala et al. have identified CLIC5A in podocytes, where it is complexed with ezrin, podocalyxin, and the actin cytoskeleton. Absence of CLIC5A results in altered podocyte morphology and proteinuria. Exactly how CLIC5A supports podocyte function is unclear. Potential mechanisms in which cytoskeletal interactions could regulate other functions of CLIC5A are discussed.
More Related Videos
Related Concept Videos
Tight Junctions
Cell Motility through Blebbing
Blebbing Through the Matrix
In multicellular...
Intracellular Signaling Affects Focal Adhesions
Some...
Mechanism of Filopodia Formation
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
Microtubules in Signaling
Reabsorption and Secretion in the PCT
Transport mechanisms involving sodium ions (Na+) contribute significantly to solute reabsorption. These mechanisms include symport and antiport processes.
A key example is the...

