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Updated: Jun 8, 2026

Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions
Published on: August 2, 2018
FIH1 (factor inhibiting HIF-1) in the kidney: more than an oxygen sensor?
Yasemin Sirin1, Hermann Pavenstädt
1Medizinische Klinik und Poliklinik D, University of Münster, Münster, Germany.
Abstract:
Factor inhibiting HIF-1 (FIH1) inhibits the activity of hypoxia-inducible factor 1 (HIF-1) by preventing HIF-1α from binding to p300/CBP. Schödel et al. demonstrate that, in the kidney, FIH1 is expressed selectively in the distal tubules and podocytes. Although FIH1 functions as a transcriptional repressor of HIF target genes in tubular cells, it does not do so in podocytes. This study suggests that FIH1 may have diverse implications for distal tubular function and podocyte biology.
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