Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
Hypodermis01:02

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dietary recommendations for persons with type 2 diabetes mellitus.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2026
Same author

<i>AstroECP</i>: towards more practical electron channeling contrast imaging.

Journal of applied crystallography·2026
Same author

Effects of Glucagon-Like Peptide-1 Receptor Agonists (Mono and Combination Therapy) on Energy Expenditure: A Scoping Review.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2026
Same author

Effect of vitamin C and hesperidin on serum uric acid concentrations in healthy adults with high uric acid levels: the randomized controlled 'HesperidrinC trial'.

European journal of nutrition·2026
Same author

Predicting resting metabolic rate in healthy adults: a comparative analysis using the <i>enable</i> cohort.

American journal of physiology. Endocrinology and metabolism·2026
Same author

A Nutritional Evaluation of Plant-Based Meat and Sausage Analogues.

Foods (Basel, Switzerland)·2025

Related Experiment Video

Updated: Jun 8, 2026

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
13:35

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos

Published on: March 21, 2021

'Functional' body composition: differentiating between benign and non-benign obesity.

Manfred J Müller1, Anja Bosy-Westphal, Martin Heller

  • 1Institut für Humanernährung und Lebensmittelkunde, Agrar- und Ernährungswissenschaftliche Fakultät, Christian-Albrechts-Universität, Düsternbrooker Weg 17-19, D-24105 Kiel, Germany. mmueller@nutrfoodsc.uni-kiel.de

F1000 Biology Reports
|October 16, 2010
PubMed
Summary
This summary is machine-generated.

Metabolically-benign obese individuals share similar body metrics with non-metabolically benign obese individuals. Functional body composition assessment is recommended over BMI for improved metabolic research and clinical decisions.

More Related Videos

Localization, Identification, and Excision of Murine Adipose Depots
08:53

Localization, Identification, and Excision of Murine Adipose Depots

Published on: December 4, 2014

Clinical Anthropometrics and Body Composition from 3-Dimensional Optical Imaging
06:48

Clinical Anthropometrics and Body Composition from 3-Dimensional Optical Imaging

Published on: June 7, 2024

Related Experiment Videos

Last Updated: Jun 8, 2026

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
13:35

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos

Published on: March 21, 2021

Localization, Identification, and Excision of Murine Adipose Depots
08:53

Localization, Identification, and Excision of Murine Adipose Depots

Published on: December 4, 2014

Clinical Anthropometrics and Body Composition from 3-Dimensional Optical Imaging
06:48

Clinical Anthropometrics and Body Composition from 3-Dimensional Optical Imaging

Published on: June 7, 2024

Area of Science:

  • Metabolic research
  • Obesity studies
  • Body composition analysis

Background:

  • Obesity is often assessed using Body Mass Index (BMI), a nutritional status-based metric.
  • Recent studies indicate that metabolically-benign obese individuals have similar BMI, waist circumference, and subcutaneous abdominal fat compared to non-metabolically benign obese individuals.
  • A significant portion of the obese population (25-30%) may not require treatment for secondary disorders.

Purpose of the Study:

  • To advocate for the replacement of nutritional status-based risk assessments with functional body composition analysis.
  • To highlight the limitations of BMI in identifying metabolic health within obese populations.
  • To emphasize the importance of functional body composition in metabolic research and clinical decision-making.

Main Methods:

  • Comparative analysis of body composition, insulin resistance, aerobic fitness, and intima-media thickness.
  • Evaluation of metabolic health markers in obese subjects.
  • Assessment of anthropometric measurements including BMI and waist circumference.

Main Results:

  • Metabolically-benign obese subjects exhibit comparable BMI, waist circumference, and subcutaneous abdominal fat to non-metabolically benign obese subjects.
  • Functional body composition provides a more nuanced understanding of nutritional status, metabolism, endocrinology, and disease.
  • Detailed body composition data can characterize biomedical traits and link genetic variants to functional evidence.

Conclusions:

  • Functional body composition assessment offers a superior approach to risk assessment compared to traditional methods like BMI.
  • This shift is crucial for advancing metabolic research and improving clinical decision-making for obese patients.
  • Understanding functional body composition is key to a sophisticated view of health, metabolism, and disease, with implications for genetic research.