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Updated: Jun 8, 2026

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing
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Abdominal compartment syndrome.

Manu Malbrain1

  • 1ZNA Stuivenberg, Lange Beeldekensstraat 267, B-2060 Antwerpen 6 Belgium.

F1000 Medicine Reports
|October 16, 2010
PubMed
Summary
This summary is machine-generated.

Abdominal compartment syndrome (ACS) and intra-abdominal hypertension (IAH) affect critically ill patients. This report clarifies IAH/ACS definitions, organ dysfunction mechanisms, and treatment options for physicians.

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Area of Science:

  • Critical Care Medicine
  • Surgical Pathology
  • Gastroenterology

Background:

  • Abdominal compartment syndrome (ACS) initially recognized in surgical patients (e.g., aneurysm repair, trauma, bleeding, infection).
  • Increasing recognition of ACS and intra-abdominal hypertension (IAH) in diverse medical conditions, including burn injury, sepsis, and non-surgical patient groups.
  • Need for updated understanding and standardized management strategies for IAH and ACS.

Purpose of the Study:

  • To provide critical care physicians with a comprehensive overview of current knowledge on intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS).
  • To focus on recent literature and guidelines from the World Society of the Abdominal Compartment Syndrome (WSACS).
  • To elucidate definitions, pathophysiology, diagnosis, and management of IAH and ACS.

Main Methods:

  • Review of recent literature pertaining to intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS).
  • Inclusion of definitions and recommendations from the World Society of the Abdominal Compartment Syndrome (WSACS).
  • Discussion of intra-abdominal pressure (IAP) measurement techniques, organ dysfunction mechanisms, and treatment modalities (medical and surgical).

Main Results:

  • Detailed listing of definitions for increased intra-abdominal pressure (IAP).
  • Comprehensive overview of the mechanisms leading to organ dysfunction in the context of IAH.
  • Discussion of the gold standard for IAP measurement and organ support recommendations.

Conclusions:

  • IAH and ACS represent significant challenges in critically ill patients across various pathologies.
  • Adherence to standardized definitions and guidelines (WSACS) is crucial for accurate diagnosis and effective management.
  • Multifaceted approach involving precise IAP monitoring, organ support, and timely medical/surgical interventions is essential for improving patient outcomes.