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Updated: Jun 8, 2026

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells
Published on: July 20, 2014
Management of Barrett's oesophagus
Jayan Mannath1, Krish Ragunath
1Nottingham Digestive Diseases Centre and Biomedical Research Unit, Queen's Medical Centre Campus Derby Road, Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH UK.
Abstract:
Barrett's oesophagus, which is thought to be a consequence of gastro-oesophageal reflux disease (GORD), is a well-recognized precursor of oesophageal adenocarcinoma. Medical therapies and anti-reflux surgeries for GORD have shown conflicting results regarding the progression of Barrett's metaplasia to neoplasia. After high-grade dysplasia or intramucosal cancer is identified, it has been standard practice to conduct an oesophagectomy, despite this having an associated risk of morbidity and mortality. In recent years however, endoscopic therapy has become a viable alternative to oesophagectomy in treating early neoplasia.
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