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Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

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Published on: March 17, 2019

Impulse control disorders in Parkinson's disease.

¹Duke University Medical Center 932 Morreene Road, MS 3333, Durham, NC 27705 USA.

F1000 Medicine Reports

|October 16, 2010

Summary

Impulse control disorders are increasingly recognized in Parkinson's disease patients, often linked to dopamine dysregulation syndrome and antiparkinson medications. These disruptive behaviors impact social and occupational functioning.

Area of Science:

Neurology
Psychiatry
Pharmacology

Background:

Parkinson's disease (PD) is associated with impulse control disorders (ICDs).
Original concepts like hedonistic homeostatic dysregulation syndrome have evolved.
Dopamine dysregulation syndrome (DDS) is now a key concept.

Purpose of the Study:

To define and characterize impulse control disorders in Parkinson's disease.
To highlight the association between ICDs and antiparkinson therapies.
To describe the spectrum of maladaptive behaviors.

Main Methods:

Literature review and synthesis of existing research on ICDs in PD.
Analysis of clinical features and diagnostic criteria.
Examination of the relationship with dopaminergic medication.

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Last Updated: Jun 8, 2026

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

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Published on: March 17, 2019

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

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Published on: January 9, 2015

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

Main Results:

ICDs, including compulsive spending, gambling, binge eating, and hypersexuality, are increasingly recognized in PD.
These behaviors are linked to disease progression and increased antiparkinson medication.
Features such as severe dyskinesias and mood disorders persist.

Conclusions:

ICD is defined as maladaptive behaviors emerging with PD progression and increased antiparkinson medication.
These behaviors can be disruptive (e.g., punding) or destructive (e.g., gambling, compulsive spending).
Understanding ICDs is crucial for managing PD patients on dopaminergic therapy.