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Updated: Jun 8, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
Published on: June 17, 2025
Diagnosis and clinical severity markers of bullous pemphigoid
Enno Schmidt1, Detlef Zillikens
1Department of Dermatology, University of Lübeck Ratzeburger Allee 160, D-23538 Lübeck Germany.
Abstract:
The use of a broad spectrum of novel detection systems for autoantibodies to the basement membrane proteins BP180 and BP230 has greatly facilitated the diagnosis of bullous pemphigoid, which most likely explains its increasing incidence in central Europe. Because the pathogenic relevance of antibodies to human BP180 has been convincingly shown both in vitro and in vivo, repeated testing for these antibodies appears to be helpful in guiding treatment decisions during the course of the disease.
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