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Does infliximab increase complications after surgery for inflammatory bowel disease?
Stefan D Holubar1, Robert R Cima, John H Pemberton
1Division of Colon and Rectal Surgery, Mayo Clinic 200 First Street SW, Rochester, MN 55905 USA.
Conflicting data exist on infliximab (anti-tumor necrosis factor-alpha antibody) therapy before surgery for Crohn disease and ulcerative colitis. This review examines literature supporting and refuting its link to post-operative complications.
Area of Science:
- Gastroenterology
- Immunology
- Surgical Complications
Background:
- Monoclonal anti-tumor necrosis factor-alpha antibody therapy, such as infliximab, is used for inflammatory bowel diseases.
- The impact of pre-operative infliximab on post-operative complications in Crohn disease and chronic ulcerative colitis remains debated.
Purpose of the Study:
- To review and synthesize current literature on the association between pre-operative infliximab and post-operative complications.
- To present evidence supporting and refuting this association.
Main Methods:
- Literature review of studies investigating pre-operative infliximab use and post-operative outcomes.
- Analysis of data from clinical trials and observational studies.
Main Results:
- Evidence is conflicting regarding increased post-operative complications after infliximab therapy.
- Some studies suggest a potential link, while others show no significant association.
Conclusions:
- The association between pre-operative infliximab and post-operative complications requires further investigation.
- Clinical decision-making should consider the available evidence and individual patient factors.
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