Related Experiment Video
Updated: Jun 8, 2026
09:40
Detection of True IgE-expressing Mouse B Lineage Cells
Published on: December 1, 2014
Regulation of the IgE response
Daniel H Conrad1, David R Gibb, Jamie Sturgill
1Department of Microbiology and Immunology, Virginia Commonwealth University Box 980678, Richmond, VA 23298 USA.
F1000 Biology Reports
|October 16, 2010
Summary
Immunoglobulin E (IgE) antibodies cause allergic diseases. This review covers recent advances in controlling IgE synthesis, focusing on T helper 2 (Th2) cell regulation and IgE Fc receptors.
Area of Science:
- Immunology
- Allergy Research
Background:
- Immunoglobulin E (IgE) is the fifth discovered immunoglobulin class.
- IgE mediates type I hypersensitivity reactions, commonly known as allergies.
Purpose of the Study:
- To review recent advancements in the control of IgE synthesis.
- To emphasize the role of T helper 2 (Th2) cells in IgE regulation.
- To explore the function of IgE Fc receptors in this process.
Main Methods:
- Literature review of recent developments in IgE synthesis control.
- Focus on Th2 cell-mediated regulatory mechanisms.
- Analysis of IgE Fc receptor interactions and signaling pathways.
Main Results:
- Recent studies highlight Th2 cells as key regulators of IgE production.
- IgE Fc receptors play a significant role in modulating IgE-mediated responses.
- Emerging strategies target Th2 pathways and Fc receptors for allergy management.
Conclusions:
- Understanding Th2 regulation and Fc receptor function is crucial for controlling IgE.
- New therapeutic targets for allergic diseases are being identified based on these mechanisms.
Related Concept Videos
01:28Inflammatory Response
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
01:15Receptor Downregulation in MVBs
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR activation may...
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR activation may...
01:24T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
01:31Regulation of the Unfolded Protein Response
Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
01:25Regulation of the Digestive System
Digestive activity regulation hinges on three primary components. Activation is prompted by a multitude of mechanical and chemical indicators, primarily detected by receptors within the stomach and intestines' walls. These receptors predominantly respond to factors such as mechanical stretching of the organ walls, changes in pH and osmolarity, and the presence of digesting materials and their by-products.
The effectors in this regulation system are glands and smooth muscles. Activation of these...
The effectors in this regulation system are glands and smooth muscles. Activation of these...
01:19Regulation of Hormone Secretion
Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral stimuli,...
Humoral stimuli,...