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Related Experiment Video

Updated: Jun 8, 2026

Multimodality Diagnosis of Mesenteric Ischemia

Multimodality Diagnosis of Mesenteric Ischemia

Published on: July 21, 2023

Diagnosing malabsorption in the intensive care unit.

Martijn B Keur¹, Albertus Beishuizen, Adriaan A van Bodegraven

¹Departments of Intensive Care and Gastroenterology, VU University Medical Center Amsterdam De Boelelaan 1117, 1081 HV Amsterdam The Netherlands.

F1000 Medicine Reports

|October 16, 2010

Summary

This summary is machine-generated.

Assessing small bowel function in intensive care is challenging. A new citrulline generation test shows promise for accurately measuring enterocyte function, aiding in early detection of malabsorption.

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Area of Science:

Critical care medicine
Gastroenterology
Biomarker development

Background:

Small bowel dysfunction is common in intensive care units (ICUs), leading to malnutrition, sepsis, and increased mortality.
Current small bowel function tests lack applicability and are confounded by factors like altered permeability and renal dysfunction in ICUs.
Fasting plasma citrulline has limited accuracy for detecting enterocyte dysfunction in critically ill patients.

Purpose of the Study:

To evaluate the potential of a novel citrulline generation test as a biomarker for small bowel function in the ICU setting.
To assess the conversion of glutamine to citrulline as a measure of enterocyte health.

Main Methods:

Development of a citrulline generation test measuring glutamine conversion to citrulline.
This conversion occurs exclusively in functioning enterocytes.
The test aims to provide a specific measure of small bowel function.

Main Results:

The citrulline generation test measures glutamine conversion to citrulline.
This conversion is exclusive to healthy enterocytes.
The test is proposed as a promising biomarker for small bowel function assessment.

Conclusions:

The citrulline generation test may overcome limitations of existing methods for assessing small bowel function in ICUs.
This test offers a specific and promising approach to identify enterocyte dysfunction.
Further validation is needed to establish its role in clinical practice.