Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Anatomy of the Genitourinary System II: Bladder and Urethra

Anatomy of the Genitourinary System II: Bladder and Urethra

The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...

Urinary Tract Calculi III: Medical Management

Urinary Tract Calculi III: Medical Management

The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...

Drugs for Treatment of Diarrhea-Predominant IBS

Drugs for Treatment of Diarrhea-Predominant IBS

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...

Urinary Bladder

Urinary Bladder

The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...

Urinary Tract Infection I: Introduction

Urinary Tract Infection I: Introduction

Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Can We Prevent Recurrent UTIs Without Antibiotics, in Both Those Who Do and Do Not Use Catheters? ICI-RS 2024.

Neurourology and urodynamics·2024

Same author

The Association Between Constipation and Lower Urinary Tract Symptoms in Parous Middle-Aged Women: A Prospective Cohort Study.

Journal of women's health (2002)·2021

Same author

Long-term adherence to clinical therapy of overactive bladder.

Translational andrology and urology·2017

Same author

Results from the reduce trial on the effect of prostate size on incident lower urinary tract symptoms in men with mild to no current symptoms: do they justify prophylactic intervention?

Translational andrology and urology·2016

Same author

Annual direct and indirect costs attributable to nocturia in Germany, Sweden, and the UK.

The European journal of health economics : HEPAC : health economics in prevention and care·2016

Same author

Estimation of bladder contractility from intravesical pressure-volume measurements.

Neurourology and urodynamics·2016

Search research articles

Related Experiment Video

Updated: Jun 8, 2026

Transurethral Instillation Procedure in Adult Male Mouse

Transurethral Instillation Procedure in Adult Male Mouse

Published on: November 2, 2017

Intravesical botulinum toxin for lower urinary tract dysfunction.

Marcus John Drake¹

¹Bristol Urological Institute Southmead Hospital, Bristol, BS10 5NB UK.

F1000 Medicine Reports

|October 16, 2010

Summary

This summary is machine-generated.

Botulinum neurotoxin offers benefits for neurogenic detrusor overactivity but its use in idiopathic cases is debated. Long-term effects and risks like impaired voiding require further investigation before widespread adoption.

More Related Videos

Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea

Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea

Published on: November 9, 2016

Related Experiment Videos

Last Updated: Jun 8, 2026

Transurethral Instillation Procedure in Adult Male Mouse

Transurethral Instillation Procedure in Adult Male Mouse

Published on: November 2, 2017

Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea

Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea

Published on: November 9, 2016

Area of Science:

Urology
Neurology
Pharmacology

Background:

Botulinum neurotoxin (BoNT) is established for neurogenic detrusor overactivity.
Its efficacy and safety in idiopathic detrusor overactivity (IDO) are less certain.
IDO management presents challenges due to potential voiding dysfunction.

Purpose of the Study:

To evaluate the clinical utility of botulinum neurotoxin for refractory idiopathic detrusor overactivity.
To assess the balance between improved storage function and risks of impaired voiding.
To identify uncertainties and long-term consequences of BoNT treatment in IDO.

Main Methods:

Review of existing literature on botulinum neurotoxin use in detrusor overactivity.
Analysis of clinical outcomes, including storage function and voiding efficiency.
Assessment of adverse events, particularly post-void residual volumes and need for catheterization.

Main Results:

Botulinum neurotoxin shows clinical benefits in neurogenic detrusor overactivity.
In idiopathic detrusor overactivity, benefits may be offset by risks of impaired voiding.
Need for intermittent catheterization is a potential consequence that impacts quality of life.

Conclusions:

Botulinum neurotoxin is a contentious treatment for refractory idiopathic detrusor overactivity.
Further research is needed to clarify long-term outcomes and risks.
Botulinum neurotoxin is not yet considered a mainstream treatment for IDO without further evidence.