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Updated: Jun 8, 2026

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Published on: April 18, 2025

Managing septic shock.

Herwig Gerlach¹, Susanne Toussaint

¹Department of Anesthesia, Critical Care and Pain Management, Vivantes - Klinikum Neukoelln Rudower Strasse 48, D-12351 Berlin Germany.

F1000 Medicine Reports

|October 16, 2010

Summary

This summary is machine-generated.

Severe sepsis and septic shock remain critical challenges with high incidence and mortality. Recent research offers hope, focusing on activated protein C and Surviving Sepsis Campaign bundle therapy for improved clinical outcomes.

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Last Updated: Jun 8, 2026

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Published on: April 18, 2025

Area of Science:

Critical Care Medicine
Infectious Diseases
Translational Research

Background:

Severe sepsis and septic shock incidence is rising, with largely unchanged mortality rates despite recent clinical trial successes.
Progress in understanding sepsis definitions, epidemiology, pathophysiology, and diagnostics is notable.
Standard and adjunctive therapies, alongside general measures like treatment bundles, are areas of active research.

Purpose of the Study:

To review recent publications on severe sepsis and septic shock.
To discuss the role of activated protein C in sepsis management.
To evaluate the impact of the Surviving Sepsis Campaign bundle therapy on clinical practice.

Main Methods:

Literature review of recent publications.
Focus on activated protein C and Surviving Sepsis Campaign bundle therapy.
Discussion of clinical implications and routine integration.

Main Results:

Recent advancements in sepsis research are encouraging.
Activated protein C remains a topic of discussion in sepsis treatment.
The Surviving Sepsis Campaign bundle therapy shows relevance for clinical application.

Conclusions:

Despite advances, severe sepsis and septic shock continue to pose significant clinical challenges.
Further evaluation of therapies like activated protein C and adherence to bundle protocols is crucial.
Integrating research findings into clinical routine may improve patient outcomes.