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Perioperative protective effects of statins
Nina Singh1, John G Augoustides
1Cardiovascular and Thoracic Section, Department of Anesthesiology and Critical Care, University of Pennsylvania Philadelphia, PA 19104 USA.
F1000 Medicine Reports
|October 16, 2010
Summary
Statins offer perioperative benefits beyond cholesterol reduction, improving vascular function and reducing complications. Further research will likely increase their use in surgical patients.
Area of Science:
- Pharmacology
- Cardiovascular Medicine
- Critical Care Medicine
Background:
- Statins are primarily known for cholesterol synthesis inhibition.
- Emerging evidence highlights statins' pleiotropic effects, including anti-inflammatory and plaque-stabilizing properties.
- These pleiotropic actions suggest potential benefits in various clinical settings.
Purpose of the Study:
- To review the pleiotropic effects of statins.
- To explore the perioperative protective effects of statins, particularly in cardiac and vascular surgery.
- To examine the expanding role of statins in diverse conditions like sepsis and venous thromboembolism.
Main Methods:
- Review of existing literature on statin pharmacology and clinical outcomes.
- Analysis of studies investigating statins' effects on vascular endothelium, oxidative stress, and inflammation.
- Examination of evidence from randomized trials and observational studies.
Main Results:
- Statins enhance vascular endothelial function and atherosclerotic plaque stability.
- They possess anti-inflammatory, antioxidant, and antithrombotic properties.
- Evidence suggests perioperative benefits, including reduced mortality and complications, and positive outcomes in sepsis and venous thromboembolism.
Conclusions:
- Statins exhibit significant pleiotropic effects that confer perioperative protection.
- Their role may expand beyond lipid management to encompass a broader range of clinical conditions.
- Further high-quality randomized trials are anticipated to solidify their perioperative application.
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