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Updated: Jun 8, 2026

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
Published on: May 17, 2018
[The HPA axis in the pathogenesis of chronic fatigue syndrome]
F Ursini1, E Succurro, A Grembiale
1Dipartimento di Medicina Interna Unità di Medicina Sperimentale e Clinica dell'Università di Catanzaro Magna Graecia, Catanzaro, Italia. francesco.ursini@yahoo.it
Abstract:
Chronic fatigue syndrome (CFS) is a clinical syndrome characterized by profound disabling chronic fatigue associated with a wide array of other physical symptoms. Its etiology is currently unknown. Among the various hypotheses, considerable interest has been placed in the hypothalamus-pituitary-adrenal axis as a possible target of the pathogenesis of CFS. This article reviews the available scientific evidence about a role of hypothalamic-pituitary-adrenal axis in the pathogenesis of chronic fatigue syndrome.
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