Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Translating genome-wide association studies at multiple scales: Drug target prioritization, cellular architectures, and organ imaging.

Cell genomics·2026

Same author

Anti-inflammatory therapy with low-dose IL-2 in acute coronary syndromes: a randomized phase 2 trial.

Nature medicine·2026

Same author

Interpretable and reproducible machine learning model for coronary calcification and segment-level stenoses stratification on computed tomography angiography.

BMC medicine·2025

Same author

PET Imaging of Carotid Atherosclerosis: Methodology, Implications, and Applications in Neurovascular Disease.

Stroke·2025

Same author

Carotid Atherosclerosis Shows Distinct Patterns of Atheroinflammation and Microcalcification Relating to Frailty and Multimorbidity.

Cerebrovascular diseases (Basel, Switzerland)·2025

Same author

A Pipeline for Automated Quality Control of Chest Radiographs.

Radiology. Artificial intelligence·2025

Search research articles

Related Experiment Video

Updated: Jun 8, 2026

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)

Published on: May 2, 2012

FDG PET imaging and cardiovascular inflammation.

Nadine Hiari¹, James H F Rudd

¹University of Cambridge, Addenbrooke's Hospital, England, UK.

Current Cardiology Reports

|October 16, 2010

Summary

Positron emission tomography with fluorodeoxyglucose offers a novel method to quantify arterial inflammation, a key factor in atherosclerotic plaque rupture and acute coronary syndromes. This technique provides a new biomarker for cardiovascular risk assessment.

Area of Science:

Cardiovascular Imaging
Molecular Imaging
Atherosclerosis Research

Background:

Acute coronary syndromes are primarily caused by atherosclerotic plaque rupture.
Plaque inflammation destabilizes fibrous caps, increasing rupture risk.
Current anatomical imaging methods (e.g., CT angiography) cannot assess arterial inflammation.

Purpose of the Study:

To review the rationale, utility, and limitations of positron emission tomography (PET) imaging for atherosclerosis.
To highlight fluorodeoxyglucose (FDG) PET as a tool for quantifying arterial inflammation.
To discuss FDG PET as an emerging biomarker for cardiovascular risk.

Main Methods:

Review of existing literature on PET imaging in atherosclerosis.
Focus on FDG as a metabolic marker for arterial inflammation.

More Related Videos

MRI and PET in Mouse Models of Myocardial Infarction

MRI and PET in Mouse Models of Myocardial Infarction

Published on: December 19, 2013

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

Related Experiment Videos

Last Updated: Jun 8, 2026

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)

Published on: May 2, 2012

MRI and PET in Mouse Models of Myocardial Infarction

MRI and PET in Mouse Models of Myocardial Infarction

Published on: December 19, 2013

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

Comparison of PET imaging with traditional anatomical methods.

Main Results:

FDG PET enables quantification of arterial inflammation across multiple vessels.
Unlike anatomical imaging, FDG PET directly measures a key component of plaque vulnerability.
This technique offers a novel approach to assessing cardiovascular risk.

Conclusions:

FDG PET is a promising imaging modality for evaluating arterial inflammation in atherosclerosis.
It represents a significant advancement beyond anatomical assessment for cardiovascular risk stratification.
Further research and clinical application of FDG PET are warranted.