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Related Concept Videos

Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...

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Updated: Jun 8, 2026

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management
08:01

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Published on: November 30, 2022

Genetic research and biobanks.

Don Chalmers1

  • 1Faculty of Law, University of Tasmania, Hobart, TAS, Australia.

Methods in Molecular Biology (Clifton, N.J.)
|October 16, 2010
PubMed
Summary

Human biobanks and genetic research databases are vital for biomedical research. International harmonization of laws and ethics guidelines is crucial for global biobanking collaborations and public trust.

Area of Science:

  • Biomedical Research
  • Genetics
  • Public Health

Background:

  • Human biobanks and genetic research databases are critical for modern biomedical research.
  • Collections range from clinical diagnostic samples to large-scale longitudinal studies.
  • Existing regulations are a patchwork of national laws, with some international uniformity emerging.

Purpose of the Study:

  • To highlight the importance of human biobanks and genetic research databases.
  • To discuss the regulatory landscape of human tissue collections.
  • To emphasize the need for international harmonization in biobanking legislation and ethics.

Main Methods:

  • Review of existing literature on biobanking regulations and ethical guidelines.
  • Analysis of international standards and trends in privacy laws and research ethics.

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  • Examination of the implications of increasing biobank collaborations.
  • Main Results:

    • Biobanks are essential for biomedical research, encompassing clinical and longitudinal collections.
    • National laws governing human tissue collections are varied but show increasing international uniformity in privacy and ethics.
    • International collaboration necessitates harmonized legislation and research regulations.

    Conclusions:

    • International harmonization of legislation and research ethics is essential for developing global biobanking collaborations.
    • Maintaining international public trust is paramount for the future of biobanking research.
    • Standardization efforts, building on OECD principles, are key to facilitating cross-jurisdictional research.