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Updated: Jun 8, 2026
12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Crusty cats: feline pemphigus foliaceus
Andrea Peterson1, Lindsay McKay
1University of Minnesota, USA.
Compendium (Yardley, PA)
|October 16, 2010
Summary
Pemphigus foliaceus (PF) is an immune-mediated skin disease in cats causing crusts and pustules. Diagnosis requires histopathology, and treatment involves lifelong immunosuppressants like corticosteroids.
Area of Science:
- Veterinary Dermatology
- Immunopathology
- Small Animal Medicine
Background:
- Pemphigus foliaceus (PF) is an autoimmune condition affecting cats.
- It manifests as pustules and crusting, primarily on the head, ears, and paws.
- Cytology may reveal acantholytic cells, but this finding is not specific to PF.
Purpose of the Study:
- To summarize the key aspects of Pemphigus foliaceus in cats.
- To outline diagnostic criteria and treatment strategies for feline PF.
- To emphasize the chronic nature and management of this immune-mediated disease.
Main Methods:
- Review of histopathological findings in feline PF cases.
- Analysis of cytological findings in suspected PF.
- Evaluation of treatment protocols including corticosteroids and other immunosuppressants.
Main Results:
- Histopathology confirms PF through subcorneal pustules and acantholytic cells.
- Cytology can suggest PF but requires histopathological confirmation.
- Successful management often involves long-term immunosuppressive therapy.
Conclusions:
- Pemphigus foliaceus is a distinct immune-mediated skin disease in cats.
- Accurate diagnosis relies on histopathology.
- Lifelong immunosuppressive treatment is typically necessary for disease remission.
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