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Updated: Aug 12, 2026

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography
Published on: July 10, 2018
[The complex assessment of disordered bronchial patency in chronic obstructive lung diseases]
Abstract:
There were 63 patients with infectious-allergic bronchial asthma and 13 patients with chronic obstructive bronchitis. The clinical and bronchoscopic manifestations of the broncho-obstructive syndrome were compared to external respiratory function (ERF) reflecting the status of bronchial patency at different levels of the bronchial tree and the measurement data on the rheological properties of bronchial secretion. A reverse interrelationship was discovered between the intensity of asphyxia attacks and patency of the distal bronchial according to the ERF estimates. A correlation was noted between the magnitude of bronchial secretion viscosity and some characteristics: intensity of asphyxia attacks, dyspnea, number of dry rales; bronchial patency according to the ERF estimates. The values of secretion viscosity turned out to be most closely interrelated with the patency of small bronchi. A correlation was discovered between the bronchoscopic findings and bronchial patency of the proximal bronchi (ERF estimates). It is believed that bronchoscopic examination plays an important part in the diagnosis of obstruction of the bronchi accessible to inspection and has a high information content. Hyperdiscrinism intensity determines in many respects the clinical manifestations of the broncho-obstructive syndrome, measurement data on viscosity and adhesion of bronchial secretion can be used for assessing the efficacy of the action on bronchial obstruction at the level of small bronchi.
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