Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Aneurysm I: Introduction

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...

Aneurysm III: Interprofessional Care

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...

Aortic Regurgitation I: Introduction

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...

Hemorrhagic Stroke ll: Pathophysiology

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...

Hemorrhagic Stroke l: Introduction

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Novel Interventional Approach to LV Pseudoaneurysm Compressing on LAD by Utilizing LAA Closure Device.

JACC. Case reports·2022

Same author

FRED flow diversion with LVIS protection of large posterior communicating artery aneurysm: the "FRELVIS" technique.

Neurosurgical focus: Video·2022

Same author

Use of drug-eluting, balloon-expandable resolute onyx coronary stent as a novel treatment strategy for vertebral artery ostial stenosis: Case series.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences·2022

Same author

Global Impact of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events: A 1-Year Follow-up.

Neurology·2022

Same author

Carotid Artery Stenting Using the Walrus Balloon Guide Catheter With Flow Reversal for Proximal Embolic Protection: Technical Description and Single-Center Case Series.

Operative neurosurgery (Hagerstown, Md.)·2022

Same author

Statins versus Nonstatin Use in Patients with Chronic Subdural Hematomas Treated with Middle Meningeal Artery Embolization Alone - A Single-Center Experience.

World neurosurgery·2022

Search research articles

Related Experiment Video

Updated: Jun 8, 2026

Creation of a Rodent Model of Abdominal Aortic Aneurysm by Blocking Adventitial Vasa Vasorum Perfusion

Creation of a Rodent Model of Abdominal Aortic Aneurysm by Blocking Adventitial Vasa Vasorum Perfusion

Published on: November 8, 2017

Progressive aneurysm development following hemodynamic insult.

Hui Meng¹, Eleni Metaxa, Ling Gao

¹Departments of Mechanical and Aerospace Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14214, USA. huimeng@buffalo.edu

Journal of Neurosurgery

|October 19, 2010

Summary

This summary is machine-generated.

Intracranial aneurysms can progress even after initial hemodynamic stress normalizes. Vascular remodeling continues the degenerative process, indicating a self-sustaining pathological response in aneurysm development.

More Related Videos

A New Murine Model of Endovascular Aortic Aneurysm Repair

A New Murine Model of Endovascular Aortic Aneurysm Repair

Published on: July 7, 2013

Related Experiment Videos

Last Updated: Jun 8, 2026

Creation of a Rodent Model of Abdominal Aortic Aneurysm by Blocking Adventitial Vasa Vasorum Perfusion

Creation of a Rodent Model of Abdominal Aortic Aneurysm by Blocking Adventitial Vasa Vasorum Perfusion

Published on: November 8, 2017

A New Murine Model of Endovascular Aortic Aneurysm Repair

A New Murine Model of Endovascular Aortic Aneurysm Repair

Published on: July 7, 2013

Area of Science:

Vascular biology
Pathology
Biomedical engineering

Background:

Hemodynamic insult is implicated in intracranial aneurysm formation.
The necessity of sustained insult for aneurysm progression remains unclear.

Purpose of the Study:

To investigate if aneurysmal degradation persists after normalization of wall shear stress (WSS) due to adaptive vascular remodeling.
To determine if initial hemodynamic insult is sufficient to drive self-sustaining aneurysm progression.

Main Methods:

Rabbits underwent carotid artery ligation to increase basilar artery (BA) flow.
Basilar termini (BTs) were analyzed histologically over 27 weeks using an aneurysm development score (ADS).
Histological changes were correlated with WSS measurements over time.

Main Results:

Progressive degenerative and aneurysmal changes were observed at the BTs in ligated rabbits.
Internal elastic lamina (IEL) loss, media thinning, and bulging increased significantly over 27 weeks.
The aneurysm development score (ADS) increased progressively, despite WSS returning to baseline within 5 weeks.

Conclusions:

Hemodynamic insult can initiate a pathological vascular response leading to self-sustaining aneurysmal remodeling.
Continued aneurysm progression does not require the persistence of the initial inciting hemodynamic factor.