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Published on: August 4, 2021
Association of vascular endothelial growth factor gene polymorphisms with recurrent spontaneous abortion in Chinese
Xiuye Xing1, Junhao Yan, Yueran Zhao
1Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China.
Problem:
An association of polymorphism -1154G/A (rs1570360) in vascular endothelial growth factor (VEGF) gene with idiopathic recurrent spontaneous abortion (RSA) has been found in Caucasians. The aim of this study was to examine the association of VEGF -1154 with RSA in a well-defined group of Chinese Han patients.
Method Of Study:
The VEGF -1154G/A genotype was detected by real-time PCR with TaqMan probes. The products were also subjected to gene sequence analysis to validate the PCR results.
Results:
The allele frequencies of VEGF -1154G/A showed no significant difference between RSA patients and the normal controls (P = 0.183). The frequencies of VEGF -1154G/A genotypes were not significantly different between RSA patients and the normal controls (P = 0.228).
Conclusion:
Our study revealed that VEGF -1154G/A polymorphism was not associated with the susceptibility to RSA in Chinese Han women.
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