Growth pattern and growth prediction of body height in children with mucopolysaccharidosis type II
Agnieszka Rozdzynska1, Anna Tylki-Szymanska, Agnieszka Jurecka
1Anthropology Laboratory, The Children's Memorial Health Institute, Warsaw, Poland. agnieszka.rozdzynska@gmail.com
Insights
Children with mucopolysaccharidosis type II (MPS II) initially grow faster than healthy peers but slow significantly, showing altered growth patterns and reduced final height. This impacts overall development and requires further study.
Area of Science:
- Pediatric endocrinology
- Genetics
- Developmental biology
Background:
- Mucopolysaccharidosis type II (MPS II) is a rare genetic disorder affecting growth and development.
- Understanding deviations from normal ontogenesis is crucial for patient management.
Purpose of the Study:
- To evaluate growth deviations in MPS II patients compared to a healthy population.
- To analyze the trajectory and structure of growth in individuals with MPS II.
Main Methods:
- Longitudinal study of 28 MPS II patients (0.5-21 years).
- Analysis of anthropometric data (height, weight, head circumference).
- Application of straight-line regression and mathematical structural growth models.
Main Results:
- Statistically significant negative growth trends observed for all measured parameters.
- MPS II patients exhibited faster-than-normal growth in the first three years, followed by a significant slowdown.
- The pubertal growth spurt structure differed significantly from reference data.
Conclusions:
- MPS II patients show distinct growth patterns, with initial rapid growth followed by deceleration.
- Body height growth structure, particularly the pubertal spurt, is significantly altered in MPS II.
- These findings highlight the profound impact of MPS II on overall ontogenesis.
Aim:
Our goal was to evaluate the level, degree and direction of deviation in the ontogenesis of patients with mucopolysaccharidosis type II (MPS II) in comparison with the healthy population.
Material And Methods:
The anthropometric data of a longitudinal study on 28 patients with MPS II, aged from 0.5 to 21 years, were used to analyse the general growth patterns in terms of height, weight and head circumference. The growth trend was assessed with the straight-line regression model. The mathematical structural growth model was used to evaluate the structure of body height growth.
Results:
A statistically significant negative growth trend for all features was found. Analysis of development structure revealed an earlier onset of the adolescent growth spurt among healthy boys and a lower current velocity of growth than expected values.
Conclusion:
During the first 3 years of life, all observed anthropometric features grew faster than normal. They slowed down by the end of the third year and, in subsequent years, reached lower values when compared with the reference charts. The values obtained from the BTT model showed the structure of body height growth, with particular emphasis on the pubertal spurt, was significantly different from the reference charts.
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