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Optimal vitamin A and suboptimal vitamin D status are common in Iranian infants
Beheshteh Olang1, Mohsen Naghavi, Delaram Bastani
1Unit for Public Health Nutrition, Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden. Beheshteh.olang@ki.se
Insights
Vitamin A deficiency was rare in Iranian infants, with 88% having optimal levels. However, 33% of infants showed insufficient vitamin D levels, a condition more prevalent in girls.
Area of Science:
- Pediatric Nutrition
- Micronutrient Status
- Public Health
Background:
- Vitamin A and D are crucial for infant health.
- Understanding their serum concentrations in infants is vital for public health initiatives.
- Previous data on vitamin A and D status in Iranian infants is limited.
Purpose of the Study:
- To investigate serum concentrations of vitamin A and vitamin D in Iranian infants.
- To determine the prevalence of vitamin A and D deficiency and insufficiency in this population.
- To identify potential demographic factors associated with suboptimal vitamin levels.
Main Methods:
- A descriptive cross-sectional study involving 7112 infants aged 15-23 months across Iran.
- Utilized unequal cluster sampling with unequal household sizes.
- Serum vitamin A and D levels were quantified using high-performance liquid chromatography.
Main Results:
- Mean serum vitamin A was 2.09 μmol/L, with rare deficiency (0.7%) and insufficiency (0.5%).
- Mean serum vitamin D was 61.3 nmol/L; deficiency was rare (2.8%), but insufficiency affected 32.9% of infants.
- Girls exhibited lower vitamin D concentrations compared to boys (p = 0.006).
Conclusions:
- Vitamin A deficiency is uncommon in Iranian infants, similar to developed countries.
- While vitamin D deficiency is rare, a significant proportion (33%) have insufficient levels, particularly girls.
- Public health strategies may need to address vitamin D insufficiency in Iranian infants, especially among females.
Aim:
Investigation of serum concentrations of vitamins A and D in Iranian infants.
Methods:
A descriptive cross-sectional study, investigating 7112 infants (15-23 months of age) from all regions of Iran, who attended health care centres from May 25 to June 2, 2001. Unequal clusters with unequal household sizes were sampled. Vitamin A and D levels were analysed with high-performance liquid chromatography.
Results:
The mean (SD) concentration of vitamin A was 2.09 (0.83) μmol/L. At a national level, 0.7% of the infants had a level indicating deficiency, and 0.5% of the infants had insufficient concentrations of vitamin A, defined as serum concentrations <0.35 and <0.7 μmol/L retinol, respectively. A total of 88% of infants had optimal concentrations (>1.4 μmol/L). The mean (SD) concentration of vitamin D was 61.3 (31.4) nmol/L. Deficiency was found in 2.8% of infants (<25 nmol/L), and insufficiency in 32.9% (<50 nmol/L). Suboptimal and optimal concentrations were found in 44% and 20%, representing 50-75 and >75 nmol/L, respectively. Girls had lower vitamin D concentrations than boys (p = 0.006).
Conclusion:
As in developed countries, vitamin A deficiency was rare in Iranian infants. Vitamin D deficiency was also rare, but 33% of infants had insufficient levels; this was more common in girls than boys.
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