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[A study of paclitaxel on inhibiting effects and mechanisms for Lewis lung carcinoma]
1Department of Pathology , The Affiliated Second Hospital , Hubei Medical University , Wuhan , Hubei 430071 , P. R. China.
Background:
To research the inhibitory effect and mechanisms of paclitaxel on Lewis lung carcinoma (LLC) of C57BLP6 mice.
Methods:
LLC cells were inoculated subcutaneously into C57BLP6 mice. Paclitaxel (10 mgPkg) was injected intraperitoneally in the treatment group for ten days. Then the growth and metastasis of LLC were observed and the apoptotic characteristics of LLC cells were detected by electron microscopy and flowcytes assay.
Results:
The average weights of the tumors in treatment group and control group were (2. 833 +/-0. 074) g and (0. 588 +/-0. 040) g ( P < 0. 01) , the average numbers of lung metastasis were 5. 500 +/-0. 926 and 1. 167 +/-0. 753 ( P < 0. 01) , and the ratio of apoptosis of LLC cells were 9. 002 % and 25. 772 %( P < 0. 01) , respectively. Some typical apoptotic cells and apoptotic bodies were observed through electron microscope.
Conclusions:
Paclitaxel can effectively inhibit the growth , development and metastasis of the implanted LLC in C57BLP6 mice and it can induce apoptosis of the tumor cells apparently.