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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...

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Linc-ing Long noncoding RNAs and enhancer function.

John S Mattick1

  • 1Institute for Molecular Bioscience, University of Queensland, St. Lucia QLD 4072, Australia. j.mattick@imb.uq.edu.au

Developmental Cell
|October 19, 2010
PubMed
Summary
This summary is machine-generated.

Long noncoding RNAs (lncRNAs) can function as enhancers, regulating gene expression during development. This suggests that these noncoding RNAs are essential components of enhancer activity.

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Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Genetics

Background:

  • Enhancers are crucial distal regulatory DNA elements controlling gene expression.
  • Gene expression regulation is vital for cellular differentiation and organismal development.

Discussion:

  • The study by Ørom et al. reveals that certain long noncoding RNAs (lncRNAs) possess enhancer-like functions.
  • These lncRNAs are transcribed from active enhancer regions, linking their function to enhancer mechanisms.

Key Insights:

  • Long noncoding RNAs can act as functional enhancers.
  • Transcription of enhancers into noncoding RNAs is integral to their regulatory role.
  • This finding redefines the understanding of gene regulation by distal elements.

Outlook:

  • Further research into lncRNA-mediated gene regulation could uncover new therapeutic targets.
  • Exploring the mechanisms by which lncRNAs perform enhancer functions is a key future direction.
  • Investigating the broader role of noncoding RNAs in developmental processes is warranted.