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Malignant mucosal melanoma treated with carbon ion radiotherapy with concurrent chemotherapy: prognostic value of
Keiichi Jingu1, Riwa Kishimoto, Jun-Etsu Mizoe
1Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Japan. kjingu@nirs.go.jp
Background And Purpose:
To evaluate the potential of apparent diffusion coefficient (ADC) value before carbon ion radiotherapy (C-ion RT) for malignant mucosal melanoma (MMM) to predict prognosis.
Materials And Methods:
We recruited 37 patients with MMM in the head and neck treated by C-ion RT with concomitant chemotherapy. Univariate and multivariate analyses of minimum ADC, mean ADC, tumor volume, age, PS, and gender were performed to identify prognostic factors.
Results:
The 3-year local control rate, distant metastasis-free survival rate and overall survival rate of all patients were 81.1%, 37.6% and 65.3%, respectively, with a median follow-up period of 19.0 months. In univariate analyses, lower minimum ADC (≤0.6380 × 10(-3) mm(2)/s) and lower mean ADC (≤1.1523 × 10(-3) mm(2)/s) were unfavorable prognostic factors for distant metastasis (p=0.029 and p=0.014, respectively), and lower minimum ADC was an unfavorable prognostic factor for overall survival (p=0.019). However, there was no significant prognostic factor of local control including ADC value. In multivariate analyses, only minimum ADC was selected as a prognostic factor of distant metastasis-free survival and overall survival (p=0.015 and p=0.006, respectively).
Conclusion:
Minimum ADC can be a prognostic factor of MMM in the head and neck after C-ion RT.
