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Relationship between changes in haemoglobin A1C and prostate-specific antigen in healthy men
Kazuhiro Ohwaki1, Fumiyasu Endo, Osamu Muraishi
1Department of Hygiene and Public Health, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan. ns-waki@med.teikyo-u.ac.jp
European Journal of Cancer (Oxford, England : 1990)
|October 19, 2010
Summary
Longitudinal data indicate a positive association between changes in hemoglobin A1C (HbA1C) and prostate-specific antigen (PSA) levels. This finding contrasts with previous studies suggesting an inverse relationship, highlighting the need for further research into diabetes and prostate cancer risk.
Area of Science:
- Endocrinology
- Oncology
- Urology
Background:
- Previous cross-sectional studies suggested an inverse relationship between diabetes and prostate cancer risk.
- An inverse association between hemoglobin A1C (HbA1C) and prostate-specific antigen (PSA) has been observed cross-sectionally.
- The underlying mechanisms for diabetes potentially reducing prostate cancer risk remain unclear.
Purpose of the Study:
- To investigate the longitudinal association between changes in HbA1C and PSA levels.
- To determine if this association is independent of plasma volume changes (indicated by hematocrit and weight).
Main Methods:
- A cohort of 5917 Japanese men aged 50+ was studied.
- Data were collected during routine health check-ups in 2006-2007.
- Multiple linear regression analysis examined the association between changes in HbA1C and PSA over one year, adjusting for covariates.
Main Results:
- A statistically significant positive association was found between increases in HbA1C and PSA levels.
- A 1-unit increase in HbA1C corresponded to a 5.7% increase in PSA (95% CI: 2.8-8.5%, p<0.001), after adjusting for age, baseline BMI, and changes in weight and hematocrit.
Conclusions:
- Longitudinal data suggest a positive association between HbA1C and PSA, contradicting prior cross-sectional findings.
- Further research is required to elucidate the complex relationship between diabetes and prostate cancer incidence.
