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Updated: Jun 8, 2026
Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
Cryptic IGH/BCL2 rearrangements with variant FISH patterns in follicular lymphoma
Cristina Baró1, Blanca Espinet, Marta Salido
1Laboratori de Citogenètica Molecular, Servei de Patologia, Hospital del Mar, Parc de Salut Mar, GRETNHE, IMIM-Hospital del Mar, Barcelona, Spain.
Abstract:
Follicular lymphoma (FL) is one of the most common non-Hodgkin lymphomas (NHL). Translocation t(14;18)(q32;q21) involving IGH and BCL2 genes represents its genetic hallmark. We present six cases of a series of 75 well diagnosed FL patients in which variant fluorescence in situ hybridization (FISH) patterns for this rearrangement were found. Moreover, G-banding cytogenetics and polymerase chain reaction (PCR) methods were unable to detect t(14;18)(q32;q21). According to our results, FISH is the best technique to define variant rearrangements of IGH/BCL2 genes and is important to detect it in cases with non-conclusive FL characteristics to avoid misdiagnosis with other NHL.
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