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Published on: July 24, 2016
Childhood myocarditis and parvovirus B19 genotypes
Julia Dina1, Florence Villedieu, Fabien Labombarda
1Virology Department, University Hospital of Caen, Av. G. Clemenceau, 14033 Caen, France. dina-j@chu-caen.fr
Summary
Human parvovirus B19 (PVB19) infection can cause myocarditis in children. Molecular analysis of PVB19 strains in three pediatric cases revealed no specific virological markers linked to the disease course.
Area of Science:
- Virology
- Molecular Epidemiology
- Cardiology
Background:
- Human parvovirus B19 (PVB19) infection is an infrequent cause of acute myocarditis.
- Three pediatric cases of PVB19-associated myocarditis occurred within a short period and geographic area.
Observation:
- A molecular epidemiologic investigation was conducted to identify potential virological factors influencing PVB19 infection course.
- PVB19 DNA was detected in multiple samples from each of the three children diagnosed with myocarditis.
Findings:
- Phylogenetic analysis of nearly complete PVB19 genome sequences (4265nt) revealed that all identified strains belonged to genotype 1a.
- Sequence comparison showed minor variations between strains from different patients (58-74 substitutions) but 100% similarity among strains from the same patient.
- No specific virological markers associated with myocarditis were identified in these pediatric cases.
Implications:
- Viral myocarditis, particularly from PVB19, may be an underdiagnosed cause of post-inflammatory cardiomyopathy.
- Further research is needed to understand the pathogenesis of PVB19-associated myocarditis and identify potential virological or host-related risk factors.
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