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Moonlighting glutamate formiminotransferases can functionally replace 5-formyltetrahydrofolate cycloligase

Linda Jeanguenin1, Aurora Lara-Núñez, Anne Pribat

  • 1Department of Horticultural Sciences, University of Florida, Gainesville, Florida 32611, USA.

The Journal of Biological Chemistry
|October 19, 2010
PubMed
Summary

Certain bacteria metabolize 5-formyltetrahydrofolate (5-CHO-THF) using glutamate formiminotransferase (FT) instead of the typically assumed 5-CHO-THF cycloligase (5-FCL). This discovery reveals an alternative pathway for folate metabolism in prokaryotes lacking 5-FCL.

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