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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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Metal-Ligand Bonds02:51

Metal-Ligand Bonds

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Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
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Published on: April 23, 2017

A ligand for CD5 is CD5.

Marion H Brown1, Erica Lacey

  • 1Sir William Dunn School of Pathology, Oxford, United Kingdom. Marion.Brown@path.ox.ac.uk

Journal of Immunology (Baltimore, Md. : 1950)
|October 19, 2010
PubMed
Summary
This summary is machine-generated.

CD5, a T cell receptor, engages in species-specific homophilic interactions via its first domain. Inhibiting this binding enhances T cell immune responses, revealing CD5

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Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Scavenger receptor cysteine-rich (SRCR) domains on membrane proteins regulate immune responses.
  • CD5 and CD6 are T cell receptors with structural similarities, both possessing three SRCR domains.
  • Defining CD5's specific cell surface interactions has been challenging due to protein denaturation.

Purpose of the Study:

  • To elucidate the molecular mechanism of CD5-mediated cell surface interactions.
  • To investigate the role of CD5 homophilic interactions in regulating immune responses.

Main Methods:

  • Purification of soluble CD5 at neutral pH to maintain biological activity.
  • Biochemical assays to assess CD5 homophilic binding.
  • In vitro functional assays using T cells and lymph node cells to evaluate immune response modulation.

Main Results:

  • CD5 mediates species-specific homophilic interactions, primarily involving CD5 domain 1.
  • Antibodies targeting CD5 block these homophilic interactions and modulate T cell responses.
  • Inhibition of CD5 homophilic binding enhances both antigen-specific and polyclonal immune responses.

Conclusions:

  • The extracellular region of CD5 regulates immunity through species-specific homophilic interactions.
  • CD5 homophilic binding plays a role in the productive engagement and regulation of immune responses.
  • These findings provide a molecular basis for CD5's function in T cell immunity.