Related Experiment Video
Updated: Jun 8, 2026

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
Published on: June 18, 2018
Clinical predictors of outcome from an Australian pharmacological relapse prevention trial
Kirsten C Morley1, Maree Teesson, Claudia Sannibale
1Discipline of Addiction Medicine, The University of Sydney, NSW 2006, Australia. kirsten.morley@sydney.edu.au
Aims:
To assess which baseline characteristics of patients predict response to treatment with acamprosate (ACAMP) and naltrexone (NTX) in alcohol dependence.
Methods:
Outcome data from a 12-week randomized controlled trial of NTX, ACAMP and placebo for alcohol dependence were analysed by multiple logistic regression analyses to determine the predictive effects of gender and the baseline measures of dependence severity, craving, depression, anxiety and readiness to change in addition to NTX and ACAMP treatment. Moderators of the effect of each medication on outcomes were also examined.
Results:
Relapse was predicted by the interaction terms of ACAMP and alcohol dependence severity, NTX and depression as well as NTX and the readiness to change measure Taking Steps. Abstinence was similarly predicted by the interaction term ACAMP and alcohol dependence severity.
Conclusion:
The efficacy of NTX and ACAMP in reducing relapse or lapse is influenced by different clinical characteristics.
Related Concept Videos
Factors Affecting Drug Response: Overview
Therapeutic Drug Monitoring: Affecting Factors
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Psychosis: Goals of Pharmacotherapy
Drug Abuse and Addiction: Pharmacological Phenomena
Drug Therapy
Antianxiety Medications

