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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...

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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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Study of exfoliative dermatitis.

P R Bharatiya1, P B Joshi

  • 1Department of Dermato-Venereology BJ Medical College and Sasson General Hospitals, Pune - 411001, India.

Indian Journal of Dermatology, Venereology and Leprology
|October 19, 2010
PubMed
Summary
This summary is machine-generated.

Exfoliative dermatitis predominantly affects older males, with psoriasis being the most common cause. Injudicious treatment and underlying conditions like malignancy can precipitate this severe skin condition.

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Area of Science:

  • Dermatology
  • Clinical Medicine

Background:

  • Exfoliative dermatitis is a severe, widespread inflammatory skin condition.
  • Understanding its causes, demographics, and diagnostic approaches is crucial for effective management.

Purpose of the Study:

  • To analyze the demographic profile, etiological factors, and diagnostic utility of investigations in exfoliative dermatitis.
  • To identify precipitating factors and associated conditions in patients with exfoliative dermatitis.

Main Methods:

  • Retrospective analysis of 46 cases of exfoliative dermatitis.
  • Review of patient demographics, clinical presentation, laboratory investigations, and skin biopsy results.

Main Results:

  • Peak incidence in the sixth decade, with a male predominance (M:F = 6.67:1).
  • Psoriasis was the leading cause (41.30%).
  • Injudicious use of topical treatments and pre-existing dermatoses precipitated 34% of cases. Malignancy was identified in two cases (43.5%).
  • Skin biopsy aided diagnosis in 40.91% of cases. Laboratory tests were limited diagnostically but useful for systemic implications.

Conclusions:

  • Exfoliative dermatitis presents a significant diagnostic and management challenge, particularly in older males.
  • Early and accurate diagnosis, often aided by skin biopsy, is essential for identifying underlying causes, including malignancy, and guiding appropriate treatment.