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Genital Herpes

Genital Herpes

Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...

Herpes

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Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...

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Related Experiment Video

Updated: Jun 8, 2026

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Published on: December 18, 2012

Managing recurrent genital herpes with acyclovir.

¹Consultant Dermatologist & Venereologist Clinical Research Centre, 250 Sector 19, Faridabad - 121002, India.

Indian Journal of Dermatology, Venereology and Leprology

|October 19, 2010

Summary

Oral acyclovir effectively manages recurrent genital herpes (RGH) by shortening healing and delaying outbreaks. Studies show RGH naturally resolves over time, even without treatment.

Area of Science:

Virology
Dermatology
Immunology

Background:

Recurrent genital herpes (RGH) poses a significant health challenge.
Current treatments aim to manage symptoms and reduce recurrence frequency.

Purpose of the Study:

To evaluate the long-term efficacy of oral and topical acyclovir in managing RGH.
To assess the natural progression of RGH over an extended period.

Main Methods:

A prospective study involving 75 RGH patients.
Comparison of oral acyclovir, topical acyclovir cream, and placebo.
Follow-up periods ranging from 4 to 8 years.

Main Results:

Oral acyclovir significantly shortened healing time and postponed recurrences in RGH patients.

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Topical acyclovir cream showed limited efficacy compared to oral administration.

The placebo group demonstrated that RGH naturally resolves over an 8-year period.

Conclusions:

Oral acyclovir is a beneficial treatment for managing recurrent genital herpes.
Topical acyclovir is less effective than oral acyclovir for RGH.
Recurrent genital herpes has a natural course and may resolve over time.