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Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...

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Related Experiment Video

Updated: Jun 8, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Drug-induced pseudolymphoma syndrome.

R R Mittal1, C Jain, R L Walia

  • 1Department of Dermatology and Venereology, Government Medical College, Patiala-147 001, India, .

Indian Journal of Dermatology, Venereology and Leprology
|October 19, 2010
PubMed
Summary
This summary is machine-generated.

Anticonvulsant drugs can cause pseudolymphoma syndrome (PS) in children, presenting with fever and swollen lymph nodes. Prompt treatment with steroids and drug withdrawal is often effective, though severe cases can be fatal.

Related Experiment Videos

Last Updated: Jun 8, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Area of Science:

  • Pediatric Medicine
  • Pharmacology
  • Dermatology

Background:

  • Anticonvulsant drugs are widely used in pediatric epilepsy management.
  • Adverse drug reactions, including hypersensitivity syndromes, can occur.
  • Pseudolymphoma syndrome (PS) is a rare but serious potential complication.

Purpose of the Study:

  • To report on five pediatric cases of pseudolymphoma syndrome (PS).
  • To identify the anticonvulsant drugs implicated in PS development.
  • To describe the clinical presentation, treatment, and outcomes of PS in children.

Main Methods:

  • Retrospective case series analysis of five children diagnosed with PS.
  • Review of medical records for drug history, clinical symptoms, and treatment response.
  • Clinical and pathological data were collected and analyzed.

Main Results:

  • Five pediatric patients (aged 6-12 years) developed PS after anticonvulsant therapy (carbamazepine or phenobarbitone).
  • Symptoms included fever, generalized lymphadenopathy, morbilliform rash (carbamazepine) or erythroderma (phenobarbitone), and hepatosplenomegaly in 4/5 cases.
  • Treatment with prednisolone and drug withdrawal resulted in cure in 4/5 cases; one patient died from congestive cardiac failure.

Conclusions:

  • Anticonvulsant-induced pseudolymphoma syndrome is a significant concern in pediatric patients.
  • Early recognition, drug withdrawal, and corticosteroid therapy are crucial for favorable outcomes.
  • Physicians should maintain a high index of suspicion for PS in children presenting with relevant symptoms after anticonvulsant use.