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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Desmosomes01:05

Desmosomes

The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein complexes comprising desmosomal...

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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Progressive symmetric erythokeratoderma.

A Ghorpade1, C Ramanan

  • 1Department of Dermatology & Venereology JLN Hospital & Research Centre, Bhilai Steel Plant, Bhilai - 490006, India, .

Indian Journal of Dermatology, Venereology and Leprology
|October 19, 2010
PubMed
Summary
This summary is machine-generated.

Progressive symmetric erythrokeratoderma (PSEK), also known as Gottron's Syndrome, was diagnosed in a 10-year-old boy. Histopathology confirmed the diagnosis of this rare skin condition.

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Area of Science:

  • Dermatology
  • Genetics
  • Histopathology

Background:

  • Progressive symmetric erythrokeratoderma (PSEK), or Gottron's Syndrome, is a rare genodermatosis.
  • Characterized by progressive, symmetric, and diffuse hyperkeratosis of the skin.

Purpose of the Study:

  • To report a case of PSEK in a pediatric patient.
  • To highlight the diagnostic confirmation through histopathology.

Main Methods:

  • Clinical examination of a 10-year-old boy presenting with characteristic skin findings.
  • Histopathological analysis of skin biopsy specimens.

Main Results:

  • The patient presented with clinical features consistent with PSEK.
  • Histopathology confirmed the diagnosis of progressive symmetric erythrokeratoderma.

Conclusions:

  • This case underscores the importance of histopathological correlation in diagnosing rare genodermatoses like PSEK.
  • Early and accurate diagnosis is crucial for potential future management strategies.