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Related Concept Videos

Desmosomes01:05

Desmosomes

The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein complexes comprising desmosomal...
Pinching-off of Coated Vesicles01:32

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Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
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Long-patch Base Excision Repair01:02

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Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Porin Insertion in the Outer Mitochondrial Membrane01:12

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Porins are beta-barrel proteins translocated to the mitochondrial outer membrane through the TOM complex into the intermembrane space. Porin precursors bind TIM chaperones within the intermembrane space and are guided to the Sorting and Assembly Machinery complex or SAM complex on the outer mitochondrial membrane.
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Updated: Jun 8, 2026

Isolation and Culture of Primary Oral Keratinocytes from the Adult Mouse Palate
06:28

Isolation and Culture of Primary Oral Keratinocytes from the Adult Mouse Palate

Published on: September 24, 2021

Punctuate porokeratosis.

A Ghorpade1, C Ramanan

  • 1Department of Dermatology and Venereology, JLN Hospital and Research Centre, Bhilai Steel Plaht, Bhilai - 490 006, India.

Indian Journal of Dermatology, Venereology and Leprology
|October 19, 2010
PubMed
Summary
This summary is machine-generated.

Punctate porokeratosis, a rare skin condition, presented as multiple lesions on a patient's palm. Histopathology confirmed the diagnosis, differentiating it from similar dermatological conditions.

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Area of Science:

  • Dermatology
  • Histopathology

Background:

  • Porokeratosis is a rare genodermatosis characterized by abnormal keratinization.
  • Punctate porokeratosis is a rare variant, typically affecting the palms and soles.

Purpose of the Study:

  • To describe a rare case of punctate porokeratosis in an 18-year-old female.
  • To emphasize the diagnostic importance of histopathology in differentiating punctate porokeratosis from other palmoplantar conditions.

Main Methods:

  • Clinical presentation of multiple punctate lesions on the right palm.
  • Histopathological examination of lesional skin biopsy.

Main Results:

  • Histopathology confirmed the diagnosis of punctate porokeratosis.
  • The characteristic histopathological features of porokeratosis were observed.

Conclusions:

  • Punctate porokeratosis is a rare condition that can affect adolescents.
  • Histopathological analysis is crucial for accurate diagnosis and to exclude other palmoplantar keratodermas.