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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Renal functional status in leprosy.

M Nadeem1, B R Garg, A K Das

  • 1Departments of Dermatology and Medicine, JIPMER, Pondicherry - 605006, India, .

Indian Journal of Dermatology, Venereology and Leprology
|October 19, 2010
PubMed
Summary
This summary is machine-generated.

Renal impairment is common in leprosy, particularly the multibacillary form. Studies show significant rates of proteinuria, low creatinine clearance, and abnormal serum creatinine and urea levels in affected patients.

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Area of Science:

  • Nephrology
  • Infectious Diseases
  • Dermatology

Background:

  • Leprosy, especially the multibacillary type, is associated with renal complications.
  • Understanding the spectrum of renal functional impairment is crucial for patient management.

Purpose of the Study:

  • To investigate the prevalence and types of renal functional impairment in leprosy patients.
  • To correlate clinical findings with laboratory markers of kidney function.

Main Methods:

  • Urine analysis including protein, epithelial casts, and hematuria.
  • 24-hour urinary protein excretion and creatinine clearance rate measurements.
  • Serum creatinine and urea level assessments.

Main Results:

  • Pedal edema observed in 30% of patients.
  • Proteinuria (3.33%), epithelial casts (13.33%), and microscopic hematuria (6.66%) detected.
  • Elevated 24-hour urinary protein excretion (53.33%) and low creatinine clearance (60%).
  • Abnormal serum creatinine (16.66%) and elevated serum urea (6.66%) noted.

Conclusions:

  • Renal functional impairment is a significant comorbidity in leprosy, particularly multibacillary leprosy.
  • Kidney function abnormalities, including proteinuria and reduced creatinine clearance, are prevalent.
  • Regular renal function monitoring is recommended for leprosy patients.