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Nylon friction dermatitis: A distinct subset of macular amyloidosis

V K Somani1, S Hari, V N Sita

  • 1Department of Skin and VD, Deccan College of Medical Sciences and Princess Esra Hospital, Shah Ali Bunda, Hyderabad, India, .

Indian Journal of Dermatology, Venereology and Leprology
|October 19, 2010
PubMed

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Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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Amyloid Fibrils

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Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...