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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
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Published on: September 26, 2019

A study of geriatric dermatoses.

V S Patange1, R J Fernandez

  • 1Department of Dermatology & Venereology, Seth GS Medical College & King Edward Memorial Hospital Mumbai, India, .

Indian Journal of Dermatology, Venereology and Leprology
|October 19, 2010
PubMed
Summary
This summary is machine-generated.

This study investigated age-related skin changes in 200 adults over 55. The most common complaint was itching, with benign lesions like cherry angiomas prevalent, and no skin cancers detected.

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Area of Science:

  • Dermatology
  • Geriatrics
  • Epidemiology

Background:

  • Aging is associated with various physiological changes, including alterations in the skin.
  • Understanding age-related cutaneous changes is crucial for geriatric care and disease management.
  • Prevalence of specific dermatoses and associated conditions in older adults requires detailed investigation.

Purpose of the Study:

  • To document the spectrum of cutaneous changes in individuals aged 55 years and above.
  • To identify the most frequent dermatological complaints and lesions in this age group.
  • To explore the association of systemic ailments and psychosomatic factors with skin conditions in the elderly.

Main Methods:

  • A cross-sectional study involving 200 patients aged 55 years and older.
  • Clinical examination to identify and categorize cutaneous lesions.
  • Data collection on patient demographics, chief complaints, dermatoses, and associated systemic conditions.

Main Results:

  • Pruritus (itching) was the most common complaint, reported by 78.5% of patients.
  • Common benign skin lesions included cherry angiomas, seborrhoeic keratosis, and naevus cell naevi.
  • No cases of cutaneous malignancy were observed; only 34.5% of dermatoses were infective. Diabetes was the most frequent associated systemic ailment, and 9.5% had a psychosomatic background.

Conclusions:

  • Aging skin commonly presents with benign lesions and pruritus, with no observed malignancies in this cohort.
  • Diabetes mellitus is a significant systemic comorbidity associated with dermatological issues in older adults.
  • Psychosomatic factors may play a role in skin conditions among the elderly, warranting further research.