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Sneddon-wilkinson disease and arthritis
1Department of Dermatological Surgery and Dermatological Reserach, Skin Institute and School of Dermatology, N block, Kailash Colony, New Delhi - 48, India.
Indian Journal of Dermatology, Venereology and Leprology
|October 19, 2010
Summary
Sneddon-Wilkinson disease, also known as subcorneal pustular dermatosis, is a rare skin condition. This report details an uncommon association between this disorder and seronegative arthritis.
Area of Science:
- Dermatology
- Rheumatology
- Internal Medicine
Background:
- Sneddon-Wilkinson disease (SWD), or subcorneal pustular dermatosis, is an uncommon chronic blistering skin disease.
- It is characterized by sterile pustules located superficially within the epidermis.
- SWD typically affects middle-aged women and is often chronic and relapsing.
Purpose of the Study:
- To report an unusual case of Sneddon-Wilkinson disease associated with seronegative arthritis.
- To review the existing literature on the co-occurrence of SWD and arthritic conditions.
- To highlight potential links and diagnostic considerations between these conditions.
Main Methods:
- Case report presentation.
- Comprehensive literature review of Sneddon-Wilkinson disease and arthritis.
- Analysis of clinical and pathological findings.
Main Results:
- The case presented an unusual association between Sneddon-Wilkinson disease and seronegative arthritis.
- Literature review identified limited but notable reports of SWD co-occurring with various forms of arthritis, particularly seronegative types.
- No specific pathognomonic link was established, but shared inflammatory pathways are suggested.
Conclusions:
- Sneddon-Wilkinson disease may present with an unusual association with seronegative arthritis.
- Further research is warranted to elucidate the potential pathomechanisms linking SWD and arthritis.
- Clinicians should consider evaluating for arthritis in patients diagnosed with Sneddon-Wilkinson disease.
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