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Updated: Jun 8, 2026

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
Published on: January 29, 2014
A study of immunoglobulins and complements (C3 & C4) in alopecia areata
R P Sharma1, D K Sharma, N K Sharma
1Departments of Dermatology, Pathology and Biochemistry, LLRM Medical Collage, Meerut (UP) 250004, India.
Abstract:
Estimation of serum Immunoglobulins (IgG, IgM and IgA) and complements (C3 and C4) was carried out in 100 cases of alopecia areata as per method described by Mancini (1965).[1] Clinically patients were divided in two groups, alopecia areata circumscribed (group I) and severe alopecia areata (group II). Significant decrease in levels of one or more Immunoglobulins were observed in most of the patients. However, Serum complements (C3 and C4) were within range of normal control values.

