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Related Concept Videos

Diabetes Insipidus I: Introduction01:29

Diabetes Insipidus I: Introduction

Definition Diabetes insipidus is a disorder marked by the production of large amounts of dilute urine because of impaired vasopressin production, release, or kidney response. The lack of effective vasopressin action limits water reabsorption in the renal collecting ducts, which leads to excessive urinary water loss and intense thirst.Clinical PresentationIndividuals with diabetes insipidus report persistent thirst and very high urine output. In severe cases, fluid intake can reach up to 20...
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Updated: Jun 8, 2026

Efficient Derivation of Retinal Pigment Epithelium Cells from Stem Cells
07:07

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Published on: March 8, 2015

Incontinentia pigmenti.

S Purohit1, M K Singhi, R Khullar

  • 1Department of Skin, STD and Leprosy, Dr Sampurnanand Medical College, Jodhpur-342003, India.

Indian Journal of Dermatology, Venereology and Leprology
|October 19, 2010
PubMed
Summary
This summary is machine-generated.

Three female patients with incontinentia pigmenti presented with unusual skin pigmentation and lesions. Notably, the typical vesicular stage and systemic involvement were absent in all reported cases.

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Area of Science:

  • Dermatology
  • Genetics
  • Pediatrics

Background:

  • Incontinentia pigmenti (IP) is a rare X-linked dominant disorder.
  • IP typically presents with a characteristic four-stage cutaneous eruption.
  • Systemic involvement can occur in infants and children with IP.

Purpose of the Study:

  • To report three unique cases of incontinentia pigmenti.
  • To highlight atypical presentations of IP.
  • To discuss the absence of the vesicular stage and systemic involvement in these cases.

Main Methods:

  • Case report analysis.
  • Clinical examination of patients.
  • Review of medical literature.

Main Results:

  • Three female patients diagnosed with incontinentia pigmenti were identified.
  • All patients exhibited bizarre skin pigmentation and verrucous/nodular lesions.
  • Absence of the characteristic vesicular stage was observed in all three cases.
  • No systemic involvement was detected in any of the patients.

Conclusions:

  • Incontinentia pigmenti can manifest with atypical cutaneous findings.
  • The absence of the vesicular stage and systemic involvement does not exclude the diagnosis of IP.
  • Further research into the phenotypic variability of IP is warranted.