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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

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Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Related Experiment Videos

Cutaneous B-cell lymphoma.

M Jayaraman1, V R Janaki, P Yesudian

  • 1Department of Dermatology, Madras Medical College and Government General Hospital, Madras, India.

Indian Journal of Dermatology, Venereology and Leprology
|October 19, 2010
PubMed
Summary
This summary is machine-generated.

Early dermatopathological interpretation is crucial for diagnosing primary cutaneous B-cell lymphoma. Misdiagnosis as vasculitis delayed treatment, leading to a poor prognosis in this case.

Related Experiment Videos

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Primary cutaneous B-cell lymphoma (PCBCL) often presents with a poor prognosis.
  • Low-grade PCBCL may exhibit a favorable prognosis.
  • Accurate early diagnosis is critical for effective management.

Purpose of the Study:

  • To highlight the importance of early and accurate dermatopathological interpretation in suspected cutaneous B-cell lymphoma.
  • To illustrate the consequences of misdiagnosis in cutaneous B-cell lymphoma.

Main Methods:

  • Case report of a 32-year-old male with atypical skin lesions.
  • Initial biopsy interpreted as vasculitis.
  • Subsequent biopsies and retrospective analysis of the initial biopsy.

Main Results:

  • Initial presentation with hyperpigmented patches misdiagnosed as vasculitis.
  • Development of nodules, plaques, and ulceration after 8 months, revealing B-cell lymphoma.
  • Retrospective review of the initial biopsy identified atypical lymphoid cells.
  • Patient's death 6 months after chemotherapy initiation.

Conclusions:

  • Emphasizes the critical role of expert dermatopathological review for early detection of cutaneous B-cell lymphoma.
  • Delayed diagnosis significantly impacts patient prognosis.
  • Atypical lymphoid cells in early biopsies warrant thorough investigation for lymphoma.