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Updated: Jun 8, 2026

Mouse Models of Periventricular Leukomalacia

Mouse Models of Periventricular Leukomalacia

Published on: May 18, 2010

Congenital leopard vitiligo associated with multiple sclerosis.

P Bhargava¹, D K Mathur, R Bhargava

¹Department of Dermatology, SMS Medical College & Hospital Jaipur, India.

Indian Journal of Dermatology, Venereology and Leprology

|October 19, 2010

Summary

Congenital leopard vitiligo, a rare skin condition, was found to be associated with multiple sclerosis in a patient and appeared to follow an autosomal dominant inheritance pattern in their family.

Related Experiment Videos

Last Updated: Jun 8, 2026

Mouse Models of Periventricular Leukomalacia

Mouse Models of Periventricular Leukomalacia

Published on: May 18, 2010

Area of Science:

Dermatology
Genetics
Neurology

Background:

Congenital leopard vitiligo is a rare genetic skin disorder characterized by distinct depigmented macules.
Multiple sclerosis is a chronic autoimmune disease affecting the central nervous system.

Purpose of the Study:

To investigate the association between congenital leopard vitiligo and multiple sclerosis.
To determine the inheritance pattern of congenital leopard vitiligo within a family.

Main Methods:

Case presentation of a 31-year-old male with congenital leopard vitiligo and multiple sclerosis.
Family history collection and pedigree analysis to assess disease transmission.

Main Results:

The patient presented with congenital leopard vitiligo and a confirmed diagnosis of multiple sclerosis.
Five additional family members exhibited similar congenital cutaneous lesions.
The observed pattern of inheritance suggested an autosomal dominant mode with variable penetrance.

Conclusions:

Congenital leopard vitiligo may be associated with neurological conditions like multiple sclerosis.
The familial occurrence indicates a potential genetic link, possibly autosomal dominant, for congenital leopard vitiligo.