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Related Concept Videos

Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Vaccine Production01:23

Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
Vaccinations01:51

Vaccinations

Overview
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...

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Generation and Genetic Manipulation of Human Cervical Organoids
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Generation and Genetic Manipulation of Human Cervical Organoids

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The path to developing a cervical cancer vaccine.

Kathrin U Jansen1

  • 1Vaccine Research & Early Development, Pfizer Inc., USA. kathrin.jansen@pfizer.com

Human Vaccines
|October 19, 2010
PubMed
Summary

This personal reflection details a vaccinologist's non-linear career path, highlighting the impact of scientific collaboration and mentorship. Key experiences involved navigating challenges and seizing opportunities in vaccine development.

Area of Science:

  • Vaccinology
  • Immunology
  • Medical Research

Background:

  • The narrative outlines a personal journey into vaccinologist career.
  • It emphasizes the non-linear progression, involving numerous decisions and diverse experiences.

Discussion:

  • The author reflects on the importance of interactions with scientists.
  • Mentorship and apprenticeships are highlighted as crucial for professional development.

Key Insights:

  • Career paths in science are often complex and unpredictable.
  • Collaboration and continuous learning are vital for scientific growth.

Outlook:

  • The reflection underscores the role of serendipity and adaptability in scientific careers.

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  • It serves as an anecdotal account of building a career in vaccine science.