Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Modeling glucose distribution in the cornea.

B E McCarey1, F H Schmidt

  • 1Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA 30322.

Current Eye Research
|November 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond the audiogram: tone decay as audiological marker for disproportional loss of speech intelligibility.

International journal of audiology·2026
Same author

Evaluation of Summer Sausage Manufactured Using Mixed Lactobacillus and Leuconostoc Starter Culture <sup>1</sup>.

Journal of food protection·2019
Same author

[TMPRSS2-ETS gene fusion in prostate cancer].

Der Urologe. Ausg. A·2007
Same author

Chemical determinants of the rat electro-olfactogram.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2000
Same author

The distribution of strain in the human cornea.

Journal of biomechanics·1997
Same author

Corneal endothelial damage by air bubbles during phacoemulsification.

Archives of ophthalmology (Chicago, Ill. : 1960)·1997

An electrical model simulates corneal glucose diffusion. Intracorneal lens permeability and power significantly impact glucose availability to the corneal epithelium.

Area of Science:

  • Ophthalmology
  • Biophysics
  • Biomedical Engineering

Background:

  • Corneal glucose is essential for epithelial health, supplied via diffusion from aqueous humor.
  • Glucose diffusion in the cornea can be modeled using electrical resistance principles.
  • Cellular glucose uptake resembles electrical current diversion.

Purpose of the Study:

  • To develop an electrical analog model of the cornea.
  • To predict epithelial glucose availability and stromal glucose distribution.
  • To analyze the impact of intracorneal lens (ICL) parameters on corneal glucose.

Main Methods:

  • An electrical analog model was created to simulate corneal glucose diffusion.
  • The model predicts glucose concentration lines and flux.

Related Experiment Videos

  • Simulations varied ICL diameter, depth, permeability, and thickness.

    • Main Results:

    • Normal corneal stroma shows glucose concentration decreasing from 880 to 580 µg/ml.
    • Intracorneal lens permeability is the primary factor affecting glucose availability.
    • ICL power, particularly minus power designs, influences central epithelial glucose levels.

    Conclusions:

    • The electrical analog model effectively predicts corneal glucose dynamics.
    • ICL design parameters, especially permeability and power, are critical for maintaining corneal health.
    • Minus power ICLs may enhance central epithelial glucose availability due to their optical zone design.